List of included PGS

The following polygenic scores are included in HRS Polygenic Score Data (PGS).

Phenotype of GWAS meta-analysis GWAS meta-analysis citation Release 1 (May 2017) Release 2 (April 2018) Release 3 (Oct 2018) Release 4 (Feb 2020)
Educational Attainment 2* Okbay (SSGAC, 2016)   2006-2012 2006-2012 2006-2012
Height Wood (GIANT, 2014) 2006-2010 2006-2012 2006-2012 2006-2012
Body Mass Index (BMI)** Locke (GIANT, 2015) 2006-2010 2006-2012 2006-2012 2006-2012
Waist Circumference (WC) Shungin (GIANT, 2015) 2006-2010 2006-2012 2006-2012 2006-2012
Waist-to-Hip Ratio (WHR) Shungin (GIANT, 2015) 2006-2010 2006-2012 2006-2012 2006-2012
Diastolic Blood Pressure (DBP) Ehret (ICBP, 2011) 2006-2010    
Systolic Blood Pressure (SBP) Ehret (ICBP, 2011) 2006-2010    
Pulse Pressure (PP) Wain (ICBP, 2011) 2006-2010    
Mean Arterial Pressure (MAP) Wain (ICBP, 2011) 2006-2010    
Alzheimer's Disease (AD) Lambert (IGAP, 2013) 2006-2010 2006-2012 2006-2012 2006-2012
General Cognition* Davies (CHARGE, 2015) 2006-2010 2006-2012 2006-2012 2006-2012
Schizophrenia Ripke (PGC, 2014) 2006-2010 2006-2012 2006-2012 2006-2012
Smoking Initiation (ever/never) Furberg (TAG, 2010) 2006-2010 2006-2012 2006-2012 2006-2012
Subjective Wellbeing* Okbay (SSGAC, 2016) 2006-2010 2006-2012 2006-2012 2006-2012
Neuroticism* Okbay (SSGAC, 2016) 2006-2010 2006-2012 2006-2012 2006-2012
Depressive Symptoms* Okbay (SSGAC, 2016) 2006-2010 2006-2012 2006-2012 2006-2012
Longevity* Broer (CHARGE, 2015)   2006-2012 2006-2012 2006-2012
Number of Cigarettes Smoked per Day (CPD) Furberg (TAG, 2010)   2006-2012 2006-2012 2006-2012
Coronary Artery Disease (CAD) Schunkert (CARDIoGRAM, 2011)   2006-2012 2006-2012 2006-2012
Myocardial Infarction (MI) Nikpay (CARDIoGRAMplusC4D, 2015)   2006-2012 2006-2012 2006-2012
Type II Diabetes (T2D) Morris (DIAGRAM, 2012)   2006-2012 2006-2012 2006-2012
Attention Deficit/Hyperactivity Disorder (ADHD) PGC 2010 Neale (PGC, 2010)   2006-2012 2006-2012 2006-2012
Attention Deficit/Hyperactivity Disorder (ADHD) PGC 2017 Demontis (PGC, 2017)   2006-2012 2006-2012 2006-2012
Autism Anney (PGC, 2017)   2006-2012 2006-2012 2006-2012
Bipolar Disorder (BIP) Sklar (PGC, 2011)   2006-2012 2006-2012 2006-2012
Mental health cross disorder Smoller (PGC, 2013)   2006-2012 2006-2012 2006-2012
Age at Menarche Perry (ReproGen, 2014)   2006-2012 2006-2012 2006-2012
Age at Menopause Day (ReproGen, 2015)   2006-2012 2006-2012 2006-2012
Plasma Cortisol Bolton (CORNET, 2014)   2006-2012 2006-2012 2006-2012
Major Depressive Disorder (MDD) Ripke (PGC, 2013)   2006-2012 2006-2012 2006-2012
Extraversion van den Berg (GPC, 2016)   2006-2012 2006-2012 2006-2012
Antisocial Behavior Tielbeek (BROAD, 2017)     2006-2012 2006-2012
Educational Attainment 3* Lee (SSGAC, 2018)     2006-2012 2006-2012
Obsessive Compulsive Disorder (OCD) (IOCDF-GC and OCGAS, 2017)     2006-2012 2006-2012
Age at first birth (combined, female, male) Barban (Sociogenome, 2016)     2006-2012 2006-2012
Number children ever born (combined, female, male) Barban (Sociogenome, 2016)     2006-2012 2006-2012
Major Depressive Disorder 2 (MDD2) Wray (PGC, 2018)     2006-2012 2006-2012
Post Traumatic Stress Disorder (PTSD: combined, European, African) Duncan (PGC, 2018)     2006-2012 2006-2012
High Density Lipoprotein (HDL) Willer (GLGC, 2013)     2006-2012 2006-2012
Low Density Lipoprotein (LDL) Willer (GLGC, 2013)     2006-2012 2006-2012
Total Cholesterol (TC) Willer (GLGC, 2013)     2006-2012 2006-2012
Anxiety (factor score, case-control) Otowa (ANGST, 2016)     2006-2012 2006-2012
General Cognition 2* Davies (CHARGE, 2018)       2006-2012
Blood urea nitrogen (BUN) - European ancestry GWAS Wuttke (CKDGen, 2019)       2006-2012
Blood urea nitrogen (BUN) - transancestry GWAS Wuttke (CKDGen, 2019)       2006-2012
Chronic kidney disease (CKD) - European ancestry GWAS Wuttke (CKDGen, 2019)       2006-2012
Chronic kidney disease (CKD) - transancestry GWAS Wuttke (CKDGen, 2019)       2006-2012
eGFR - European ancestry GWAS Wuttke (CKDGen, 2019)       2006-2012
eGFR - transancestry GWAS Wuttke (CKDGen, 2019)       2006-2012
Diastolic blood pressure (DBP)* Liang (COGENT, 2017)       2006-2012
Hypertension (HTN)* Liang (COGENT, 2017)       2006-2012
Pulse pressure (PP)* Liang (COGENT, 2017)       2006-2012
Systolic blood pressure (SBP)* Liang (COGENT, 2017)       2006-2012
Body Mass Index 2 (BMI2)** Yengo (GIANT, 2018)       2006-2012
Height 2** Yengo (GIANT, 2018)       2006-2012
Age at smoking initiation (AI)* Liu (GSCAN, 2019)       2006-2012
Cigarettes per day (CPD)* Liu (GSCAN, 2019)       2006-2012
Alcoholic drinks per week (DPW)* Liu (GSCAN, 2019)       2006-2012
Smoking cessation (SC)* Liu (GSCAN, 2019)       2006-2012
Smoking initiation (SI)* Liu (GSCAN, 2019)       2006-2012
Lifetime cannabis use Pasman (ICCUKB, 2019)       2006-2012
Alzheimer's disease - pT=1 with APOE/TOMM40 region Kunkle (IGAP, 2019)       2006-2012
Alzheimer's disease - pT=1 without APOE/TOMM40 region Kunkle (IGAP, 2019)       2006-2012
Alzheimer's disease - pT=0.01 with APOE/TOMM40 region Kunkle (IGAP, 2019)       2006-2012
Alzheimer's disease - pT=0.01 without APOE/TOMM40 region Kunkle (IGAP, 2019)       2006-2012
HbA1c - African ancestry GWAS Wheeler (MAGIC, 2017)       2006-2012
HbA1c - European ancestry GWAS Wheeler (MAGIC, 2017)       2006-2012
Alchol dependence - unrelated, European ancestry GWAS Walters (PGC, 2018)       2006-2012
Educational Attainment 3* with 23andMe GWAS Lee (SSGAC, 2018)       2006-2012

*The GWAS Meta-analysis was re-analyzed without the HRS cohort to produce weights independent of the HRS contribution
**The GWAS Meta-analysis includes HRS and has not been re-run without the HRS
All other GWAS did not include HRS

References

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Wood, A. R., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., ... & Amin, N. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46(11), 1173-1186.

Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., ... & Croteau-chonka, D. C. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206.

Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Locke, A. E., Mägi, R., ... & Workalemahu, T. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187.

Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., ... & Okamura, T. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), 103-109.

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Schunkert, H., König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., ... & Absher, D. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics, 43(4), 333-338.

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Day, F. R., Ruth, K. S., Thompson, D. J., Lunetta, K. L., Pervjakova, N., Chasman, D. I., ... Murray, A. (2015). Large-scale genomic analyses link reproductive ageing to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47(11), 1294–1303. http://doi.org/10.1038/ng.3412

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Liang J, Le TH, Edwards DRV, et al. Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations [published correction appears in PLoS Genet. 2018 May 11;14 (5):e1007345]. PLoS Genet. 2017;13(5):e1006728. Published 2017 May 12. doi:10.1371/journal.pgen.1006728

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Pasman JA, Verweij KJH, Gerring Z, et al. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia [published correction appears in Nat Neurosci. 2019 Jul;22(7):1196]. Nat Neurosci. 2018;21(9):1161–1170. doi:10.1038/s41593-018-0206-1

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj A, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019 Mar;51(3):414-430. doi: 10.1038/s41588-019-0358-2.

Wheeler E, Leong A, Liu CT, et al. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Med. 2017;14(9):e1002383. Published 2017 Sep 12. doi:10.1371/journal.pmed.1002383

Walters RK, Polimanti R, Johnson EC, et al. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018;21(12):1656–1669. doi:10.1038/s41593-018-0275-1

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