Two additional epigenetic clocks have been constructed using the DNA methylation data derived from the 2016 Health and Retirement Study Venous Blood Study, PACE (Belsky 2022) and GrimAge Version 2 (Lu 2022). This release serves as a supplement to the file including thirteen epigenetic clocks that was released in 2020. In addition, in this release we provide epigenetic principal components and cell subsets (identical to those released by NIAGADS) for use as covariates in analyses using the clock data, where desired.
DNA methylation assays were done on a subsample (n=4,104) people who participated in the 2016 Venous Blood Study. The sample includes all the participants of the 2016 Healthy Cognitive Aging Project (HCAP) who have provided blood samples, younger participants designated for future HCAP assessments, and a subsample of HCAP non-participants. This subsample fully represents the entire HRS sample
The full QC’d HRS 2016 DNA methylation data from which these were constructed are available through NIAGADS.
References
Belsky D.W., Caspi A, Corcoran D.L., et al. (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife, 11:e73420.
Lu A.T., Binder A.M., Zhang J, et al. (2022). DNA methylation GrimAge version 2. Aging (Albany NY), 14(23), 9484.
Product Details
| Latest Release |
Dec 2025
(V1.0)
|
|---|---|
| DOI | |
| Citation |
Health and Retirement Study (2025). HRS Epigenetic Clocks: Supplement (V1.0) [Data set]. Produced and distributed by the University of Michigan with funding from the National Institute on Aging (grant number NIA U01AG009740). https://doi.org/10.7826/DKDL7169 |
| Documentation |
Data Files
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